Taking its name from the American Indians’ Sioux Tribe and the Big Sioux River waterfalls, this city is South Dakota’s cultural heart. The annual SculptureWalk is the nation’s largest exhibit of public art; a permanent addition came last year with the stainless-steel Arc of Dreams spanning the river, its 85-foot high center gap representing the leap of faith that dreamers take to see their wishes come true. Biomedical, finance and banking, and advanced manufacturing are some of the key industries. With excellent Connectivity (#18, due to 14 direct flights to U.S. cities) and Convention Center size (#55, owing to the 100,000 square-foot Convention Center being connected to a hotel, arena, and 12,000-seat Denny Sanford PREMIER Center), Sioux Falls ranked #29 for Product overall. It also made it into our top 50 for Programming, at #42, with strong results for Nightlife (#21) and Restaurants (#40). A #50 for Promotion stemmed from a multiway tie at #9 for Google Trends and #38 for TripAdvisor Reviews. Future bragging rights: the mega site of Foundation Park will have full rail service by BNSF Railway and boost the area’s marketability for shipping, receiving, and new business.